Degenerative disease of the spinal cord causing progressive paralysis
Symptoms Loss of coordination (ataxia) in the hind limbs until paraplegia, loss of urinary and fecal continence. If signs progress for a longer period of time, eventually weakness will develop in the front limbs.
Gene involved SOD1
Mutation tested c.118G>A
Transmission mode : Autosomal recessive Frequency : Not available
Publication : Awano et al. (2009). Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis.